I have once again fallen behind in Rounding Up the news, so here play catch up, over what has been a very busy two months.
- In a world first, a Chinese group have used a . Whereas CRISPR cuts DNA, base editing directly changes the base, leaving the DNA strand intact. The paper is from the same group that published the first CIRSPRing of human embryos.
- A survey of Americans found that about . About a third were supportive of genome editing for enhancement reasons.
- , using Zing fingers to target Hemophilia A. Meanwhile, Reuters reports that the .
- The scientist who edited the first human embryo in the US stresses that the main result of his work was that the embryo did not incorporate the supplied “healthy” DNA, but instead preferentially incorporated an extra copy of the mother’s DNA. This .
- Following news of germline human genome modification, several genetic professional societies on the future of the technology, covering the following positions: “(1) At this time, given the nature and number of unanswered scientific, ethical, and policy questions, it is inappropriate to perform germline gene editing that culminates in human pregnancy. (2) Currently, there is no reason to prohibit in vitro germline genome editing on human embryos and gametes, with appropriate oversight and consent from donors, to facilitate research on the possible future clinical applications of gene editing. There should be no prohibition on making public funds available to support this research. (3) Future clinical application of human germline genome editing should not proceed unless, at a minimum, there is (a) a compelling medical rationale, (b) an evidence base that supports its clinical use, (c) an ethical justification, and (d) a transparent public process to solicit and incorporate stakeholder input.”
- A version of , with potential clinical applications e.g. to Huntingtons.
- , help in Berkeley in August, was designed to pull people to talk about a world with genome editing.
- A great for seeing how up to the times you are on genetic engineering. Contains reference to several of the recent major stories.
- Meanwhile tackles the pros and cons of genome editing.
- And a nice from Ed Yong of what the recent human embryo editing means and doesn’t mean.
And on making babies
- Some men are infertile because they have XXY or XYY sex chromosomes. Scientists have demonstrated a technique in mice where they via stem cells, loosing one of the extra chromosomes along the way.
- On that note, a review of , with a particular focus on making artificial gametes.
- The FDA has sent a to the NYC based doctor who was offering mitochondrial transfer to couples (so called three person babies, legal in the UK).
- Helix has finally . At a time when skepticism of the value genetics can deliver to healthy people is running high. Helix state that they have a rigorous scientific review process that will help them differentiate in the marketplace.
- Color has expanded its genetic screening tests to familial hypercholesterolemia, an inherited heart condition – but .
- An old story, but the on insurers being worried that predictive genetic tests will destroy insurance markets.
- for keeping most of one’s genome private, while still allowing particular clinical questions to be answered.
- Looking at the genomes of 147 humans who lived over the last few thousand years, a new study reports that we are much more genetically healthy than our ancient ancestors (with the notable exception of mental health issues), though this trend does not hold for the last 500-1000 years (, ).
- Evidence that .
- Craig Venter published an article saying that , as facial features can be recreated from DNA. The paper was by proponents of open data.
- A DTC genetics company is , in the wake of being sued by a customer who claims his data was shared without his consent in breach of the law. Genetic law has had few tests, so this will be a case to watch.
- A Nature paper using a CRISPR variant to screen for .
- A has performed well in a Chinese study. The test looked for the DNA of the Epstein-Barr virus, which has a known association to the cancer. The leader of the study, Dennis Lo, is a founder of Cirina, a small company that recently merged with Grail.
- The authors of a argue that in many cases it is useful to sequence the metastatic tumor.
- Single color digital PCR as a way to individualized assays.
- Promising results for using TEC-Seq.
- The CMO at Intel has of biohacking, in a talk at def con entitled “Genetic Diseases to Guide Digital Hacks of the Human Genome: How the Cancer Moonshot Program will Enable Almost Anyone to Crash the Operating System that Runs You or to End Civilization.”
- – headline of an article reporting on a cleverly designed sequence of DNA, that when read from As, Cs, Gs and Ts into binary, which reads as an ASCII shell command.
- A new across the planet, spearheaded by the Smithsonian.
- The FDA gets raw data from every clinical trial submitted to it, and it wants to data mine that trove to .